Just a heads up if anyone else has a problem with this.
I use a Google libraries plugin and when activated it caused TinyMCE and plupload problems with FireFox 6. Couldn’t enter text or click on an icon in the editor.
If I deactivated the PLupload plugin TinyMCE worked fine.
I narrowed it down to the Google Libraries plug-in, deactivated it and both TinyMCE and PLupload work fine.